;(21)– [PubMed]; Constantopoulos A, Karpathios T, Nicolaidou P, Maounis F, Matsaniotis N. Lazy-leukocyte syndrome. A case report . The lazy leukocyte syndrome was first described by Miller et al. in in two children with recurrent infection. They had normal humoral and cellular immunity . – LAZY LEUKOCYTE SYNDROME. LAZY LEUKOCYTE SYNDROME. Clinical Synopsis Toggle Dropdown. Inheritance. -? Autosomal dominant new.

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A bonus to all MIMmatch users is the option to sign up for updates on new gene-phenotype relationships. While the OMIM database is ,azy to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.

Single cases were reported by Costanopoulos et al.

A characteristic abnormality of actin distribution in neutrophils was demonstrated. Pathology of chemotaxis and random mobility.

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Lazy leukocyte syndrome | definition of lazy leukocyte syndrome by Medical dictionary

We are determined to keep this website freely accessible. Transient ‘lazy-leukocyte’ syndrome during infancy.

Relative to the genetics and the possibility that these cases represent new dominant leukocye, parental age data would be of interest. Expert curators review the literature and organize it to facilitate your work. Unfortunately, it is not free to produce. The same abnormality probably leads to impaired deformability of neutrophils so that release of newly formed neutrophils from the bone marrow is reduced.

A poor neutrophil response was obtained upon stimulation with both epinephrine and endotoxin, lazu well as upon induced inflammation by the Rebuck skin window technique. Please consider making a donation now and again in the future. A severe neutropenia was found.

lazy leukocyte syndrome

Autosomal dominant new mutations. None is familial and no parental consanguinity is known. The syndrome is distinguished from neutrophil chemotactic deficiencies by the coexistence of defective random motility and peripheral blood neutropenia with normal bone marrow granulocyte reserve. Skin window mobilization test and chemotaxis were normal. A new disorder of neutrophil function.


Leukocyte phagocytosis and bactericidal activity were normal.

Bone marrow studies showed normal numbers of mature, morphologically normal neutrophils. Miller knew of 4 other cases. Mobilization of leukocytes after exercise was defective.

Lazy leukocyte syndrome.

Both random mobility and chemotactic function were defective. OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. Clinical Synopsis Toggle Dropdown.

Looking For More References? We need long-term secure funding to provide you the information that you need at your fingertips. The year-old proposita had neutropenia and an illness suggestive of persistent Epstein-Barr virus infection.