Xanthogranulomatous cholecystitis (XGC) is an uncommon The files of the department of histopathology at the. Royal Hallamshire Hospital. Xanthogranulomatous cholecystitis is a rare inflammatory disease of in a review of 40 cases from the Armed Forces Institute of Pathology [3]. General. Uncommon ~ %. Approximately 2% in one series of gallbladders. May be confused (clinically) with gallbladder carcinoma.

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There were also multiple black pigmented gallstones ranging from 0. A year-old male was admitted to Chonnam National University Hospital with a day history of right upper quadrant pain with fever.

Ultrasonographic examination showed an inhomogenous, hypoechoic wall thickening of the gallbladder with internal small stones and no dilatation of intrahepatic bile ducts Fig.

It means that both XGC and gallbladder cancer are complications of gallstone and inflammation of the gallbladder, or it may suggest that tissue disruption by cancer facilitates extravasation of bile into the gallbladder wall Cytopathologic diagnosis of xanthogranulomatous cholecystitis and coexistent lesions.

Eur J Radiol 82 9: Xanthogranulomatous cholecystitis XGC is an uncommon, focal or diffuse destructive inflammatory disease of the gallbladder that is assumed to be a variant of conventional chronic cholecystitis. J Am Coll Surg. Grossly the lesions are usually soft, yellow to brown, and measure up to 2.

Histologically, the nodules are predominantly composed of abundant lipid-laden macrophages, inflammatory cells and fibroblasts. Rebound tenderness or hepatosplenomegaly was not found. Yellow brown, poor to well demarcated foci of wall thickening with variable ulceration, simulates neoplasm. Coagulation profiles were PT More recently, these terms, together with other labels, such as ceroid granuloma, ceroid-like histiocytic histolathology of the gallbladder 2 and biliary granulomatous cholecystitis 3have been abandoned in favor of XGC, a descriptive term first used by McCoy et al 4.


Xanthogranulomatous cholecystitis

Cross sections through the wall revealed multiple yellow-colored, nodule-like lesions ranging from 0. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. This is usually seen in association with dense fibrous tissue.

Or here for information on linking to our website or using our content or images. It has been suggested that xanthogranulomatous cholecystitis can be divided into two forms: A retrospective Cohort study.

Pathology of Xanthogranulomatous Cholecystitis – Dr Sampurna Roy MD

Xanthogranulomatous cholecystitis ; Gallbladder cancer. Retrospective analysis xanthogfanulomatous 12 cases. On admission, the patient was febrile and had tenderness on deep palpation to the right upper quadrant. Histopathological study and classification.

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Previous reports have suggested that cholecystiris important process is the extravasation of bile into the gallbladder wall, either from ruptured Rokitansky-Aschoff sinuses or focal mucosal ulceration 25. J Minim Access Surg 9 3: On intraoperative cholangiogram through the cystic duct after cholecystectomy, there was no evidence of remaining stone or bile duct dilatation.

There were multiple black pigmented gallstones ranging from 0.

Benign tumors and pseudotumors of the gallbladder: Gallstones are present in most patients. On operation, the gallbladder wall was thickened and the serosa were surrounded by dense fibrous adhesions which xanthogranulomatoys often extensive and attached to the adjacent hepatic parenchyma. A prospective study of 31 cases.

No metaplasia, nuclear atypia or dysplasia is apparent. Despite the possible association between XGC and gallbladder cancer, XGC is not believed to be a premalignant lesion Images hosted on other servers: In conclusion, XGC is difficult to differentiate from other forms of cholecystitis and, sometimes, from gallbladder cancer, clinically and radiologically.


The pathologic findings showed the collection of foamy histiocytes containing abundant lipid in the cytoplasm and admixed lymphoid cells. Home About Us Advertise Amazon. Genetic analysis of xanthogranulomatous cholecystitis: There was no regional lymph node enlargement or focal mass in the liver. Lipid is ingested by macrophages, which have the appearance of xanthoma cells and giant cells of foreign- body and Touton type. CASE A year-old male was admitted to our hospital with a day history of right upper quadrant pain with fever.

There was a small-sized abscess in the gallbladder wall near the cystic duct. Retrieved from ” histopatholovy Ultrasonographic examination showed an inhomogenous, hypoechoic wall thickening of the gallbladder with internal small stones, and no dilatation of intrahepatic bile ducts.

The most useful indication of percutaneous needle biopsy would, perhaps, be in advanced gallbladder cancer, as unnecessary laparotomy could be avoided.

Xanthogranulomatous cholecystitis – Libre Pathology

Ceroidlike histiocytic granulomas of gallbladder. XGC may be a high risk of postoperative wound infection and other septic complications because of frequent adhesion and abscess formation. Gallbladder Cholecystitis Xanthogranulomatous cholecystitis Author: Nippon Geka Gakkai Zasshi. Foamy macrophages and chronic inflammatory cells. Xanthogranulomatous cholecystitis is a destructive inflammatory disease of the gallbladder, rarely involving adjacent organs and mimicking an advanced gallbladder carcinoma.

Address reprint requests to: A clinical and pathologic study of twelve cases.