Geomatrix technology (Jago Pharma, Muttenz, Switzerland) can control release of one or more drugs from a tablet containing different drugs in different layers. Download/Embed scientific diagram | Geomatrix Technology: two-and three-layer systems. from publication: Development of Controlled Release Three-layered. Geomatrix is the smartest solution to grow your retail sales, available in 67 countries. We integrate best official data and technologies in a single platform.
|Published (Last):||18 March 2013|
|PDF File Size:||3.52 Mb|
|ePub File Size:||17.76 Mb|
|Price:||Free* [*Free Regsitration Required]|
Caffeine and ibuprofen were used as model drugs as they have different solubilities and allowed for a comparison on the drug release profiles. It has been made known that, altering the geometry of the core can change the drug release kinetics into zero-order or even first order if desired as indicated in Table 2. Techhnology patent by Iyer and his co-workers reported on a triple-layered system that was comprised of a sustained release layer containing methylcobalamin while the other two immediate release layers each contained an antihypertensive, and a lipid regulator or a serum homocysteine lowering agent providing a valuable combination for gfomatrix treatment of hypertension [ 88 ].
The indentation was sprayed with a coating solution with only the bottom of the indentation being sufficiently coated. The system consisted of a disc-shaped matrix core that was compression-coated on one surface as well as at the circumference in technolofy to form a cup around the core. Three different types of matrices were formulated.
The results indicated that Ibuprofen was released at a near zero-order rate for 18 hours for tchnology cup tablets that had a final depth of 4 mm [ 99 ]. However, other factors also need to be controlled in order to achieve zero-order drug release.
One of the principles involved in altering the geometry of tablets is to create a constant surface area for drug release to enable tecchnology achievement of zero-order kinetics [ 4243 ].
Drug release studies were performed over 12 hours and the results indicated that these tablets were successful in delivering two types of drugs concurrently [ 83 ].
A multi-layered controlled release tablet containing naproxen and naproxen sodium salt was developed by Desai in The tablets also proved to be feasible to manufacture on a larger scale. A flexible technology for the linear, pulsatile and delayed release of drugs allowing for easy accommodation of difficult in vitro targets. The tablet demonstrated success in delivering nifedipine at a relatively constant rate technologg 24 hours [ 94 ].
According to shape of core, zero-order kinetics. Dissolution studies over 16 hours showed that the entire amount of drug was released in a zero-order manner with no initial burst release [ 9 ]. Bilayered and triple-layered tablets were prepared using the core tablet. Structure of the Device A study undertaken by Efentakis and co-workers illustrated that the structure of a system plays an important role in its drug release behavior.
In general, the mechanisms by which polymers perform their functions are by erosion [ 56 ], dissolution and swelling [ 57 ]. A study by Kim investigated drug release from uncoated compressed tablets that contained a single central hole.
A kinetic model to explain the zero-order release of drugs from ionic polymeric drug conjugates: The matrix erodes in a controlled fashion in order to maintain blood levels. Type of polymer used, thickness of layers. A US patent by Faour and co-workers described a multilayered osmotic device that could deliver more than one pharmaceutical agent. This geomstrix of release could be useful for drugs that need a high plasma concentration immediately for therapeutic efficacy where zero-order drug release kinetics is not required.
The efficiency of cup tablets with varying depths and the optimal formulation in terms of drug release were investigated in the study. Open in a tecgnology window.
Uniformly dispersed drug core containing a hole. The triple layered tablet is composed of a drug core that has a specific shape. A study by Yang and co-workers proposed a drug delivery system gromatrix would be able to treat Helicobacter pylori -associated gastric ulcers.
Transport mechanisms and device design. Peak-to-trough fluctuations as depicted in Figure 1 may occur with first-order drug release that may cause dose dependent side effects [ 1516 ]. The relatively low dosage of this drug facilitates the rather complex dosage tchnology design. Triple-Layered Tablets Triple-layered tablets are comprised of an inner drug core layer which is sandwiched between two surrounding barrier layers [ 464 ].
This type of drug release does not allow for appropriate plasma drug level balance. Design and evaluation of transdermal drug delivery of ketotifen fumarate. Zero-order release from biphasic polymer hydrogels.
Geomatrix Technology – Oral Drug Delivery – Doctor Steve Abel
Controlled-Release Technology, Pharmaceutical Applications. Controlled release from triple layer, donut-shaped tablets with enteric polymers.
The technology proved to have potential benefits in terms of providing flexible drug release by increasing the amount of modules in an arrangement. When the core tablet came into contact with the dissolution medium, it swelled and expanded.
Polymers for sustained macromolecule release: New polymer enables near zero order release of drugs. Overall, the study showed that the characteristics of the polymers employed had a significant influence on the release profiles of the tablets although the choice of polymers employed in the study was conservative. Two types of polymers, namely rapidly erodible and slowly erodible polymers, were investigated. Coupling of diffusion and relaxation. This system showed fine potential for providing enhanced bioavailability and targeted delivery to the small intestine.
Oral Drug Delivery Systems Comprising Altered Geometric Configurations for Controlled Drug Delivery
One tablet layer comprises a degradable barrier, and the other layer contains the active in a hydrophilic matrix. In the first type, the two barrier layers were hydrophilic, in the second type, one of the barriers was hydrophobic while the other was hydrophilic and in the third type, the two barrier layers were both hydrophobic [ 65 ]. Compressed mini-tablets were designed for biphasic delivery of drugs with zero-order release kinetics [ 8889 ].
The weight and thickness of the barrier layers also had a pivotal role in drug release behavior [ 70 ]. Press coating is a good technique for producing this type of time-dependent release. A study undertaken by Efentakis and co-workers illustrated that the structure of a system plays an important role in its drug release behavior.
Multilayered hydrophilic matrices as constant release devices.