LRRTM1 leucine rich repeat transmembrane neuronal 1 [ (human)]. Gene ID: , updated on 7-Dec This gene is imprinted, being predominantly expressed from the paternal allele and showing a variable pattern of maternal down-regulation. May be associated . Leucine-rich repeat transmembrane neuronal protein 1. Gene. Lrrtm1. Organism. Mus musculus (Mouse). Status. Reviewed-Annotation score: Annotation.
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Do not show this lfrtm1 again. Comparative Toxicogenomics Database More The Gene Browser allows to navigate the human genome and investigate the relationship between PDB entries and genes.
A ruler that provides location information. Tissue x Stage Matrix.
IPR Leucine-rich repeat domain superfamily. The displayed sequence is further processed into a mature form. Am J Hum Genet. Abstract Left—right asymmetrical brain function underlies much of human cognition, behavior and emotion.
We then found direct confirmatory evidence that LRRTM1 is an imprinted gene in humans that shows a variable pattern of maternal downregulation. See other articles in PMC that cite the published article. Expression of Lrrtm1 was detected in cerebral cortex, cerebellum and brain stem, but it was biallelic Figure S5. Molecular Function carbohydrate derivative binding cytoskeletal protein binding DNA binding enzyme regulator hydrolase ligase lipid binding oxidoreductase RNA binding signaling receptor activity signaling receptor binding transcription transferase transporter.
OMIM Entry – * – LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN 1: LRRTM1
There is no fixed amino acid difference between human LRRTM1 and chimpanzee LRRTM1, and it is not among the genes that are differently expressed between adult humans and adult chimpanzees in brain, liver, kidney, heart or testis. Please consider making a donation now and again in the future. Protein interaction database and analysis system More Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: However, we cannot rule out a subtle asymmetry of function or expression at some restricted time point during human brain development, as for the transcription lgrtm1 LMO4.
SynGO Inferred from direct assay i glutamatergic synapse Source: This track represents the gene-structure on the genome. This was no more than the expected false-positive rate. LRRTM1 is a brain-expressed imprinted gene that encodes a leucine-rich repeat transmembrane protein that interacts with neurexins and neuroligins to modulate synaptic cell adhesion in neurons.
Database of comparative protein structure models More UniGene gene-oriented nucleotide sequence clusters More In geje present study we have used genetic association mapping and gene-functional analysis to identify a novel imprinted gene on 2p12, LRRTM1, that we propose is responsible for causing the linkages of this chromosomal region to human handedness and schizophrenia.
Number of PDB entities unique chains for this gene: The failure to replicate may nonetheless be related to modest power in the Chinese sample of families. National Center for Biotechnology InformationLrrmt1.
Leucine-rich repeat transmembrane neuronal protein 1
Four SNPs in distinct locations rs, rs, rs and rs; Table S1which were not in significant linkage disequilibrium LD with one another, showed nominally significant paternal-specific association with relative hand skill 0. Click on grid cells to view annotations.
December 5, This is version of the entry and version 1 of the sequence. Hand preference and hand skill in families with schizophrenia.
LRRTM1 – leucine rich repeat transmembrane neuronal 1
Mapping of an imprinted quantitative-trait-locus QTL for human handedness. Attending to local form while ignoring global aspects depends on handedness: MGI glutamatergic synapse Source: Peters AH, Schubeler D. ProteomicsDB human proteome resource More