La maladie d’Unverricht-Lundborg (MUL) est une épilepsie myoclonique caractérisée par la survenue, chez le grand enfant ou le jeune adolescent, de crises. BAFME must be differentiated from epilepsy syndromes with prominent myoclonus features. Patients may easily be misdiagnosed as having juvenile myoclonic. Juvenile myoclonic epilepsy (JME), also known as Janz syndrome, is a fairly common form of generalized epilepsy of presumed genetic origin representing.

Author: Mem Kalar
Country: Bulgaria
Language: English (Spanish)
Genre: Personal Growth
Published (Last): 28 November 2015
Pages: 72
PDF File Size: 16.24 Mb
ePub File Size: 18.99 Mb
ISBN: 424-5-89340-189-9
Downloads: 96658
Price: Free* [*Free Regsitration Required]
Uploader: Mikazuru

There was a problem providing the content you requested

EpilepsyJuvenile myoclonic epilepsyLamotrigine. Other search option s Alphabetical list. Check this box if you wish to receive a copy of your message. Features of juvenile myoclonic epilepsy. Channelopathies Epilepsy types Syndromes. In some cases, epilepsy may be difficult to treat.

Juvenile myoclonic epilepsy – Wikipedia

The search for epilepsy genes in juvenile myoclonus epilepsy: At an advanced age, a worsening of the myoclonus is possible as well as difficulty walking and mild ataxia. Electroencephalographic EEG findings include a photomyoclonic response along with abnormality of polyspikes and waves. Evaluation of a putative major susceptibility locus for juvenile myoclonic epilepsy on chromosome 15q You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.


Lamotrigine is an anti-epileptic drug considered as a first-line therapy in idiopathic generalised epilepsy.

Juvenile myoclonic epilepsy

Am J Med Genet ; epjlepsie Personal information regarding our website’s visitors, including their identity, is confidential. With successful treatment, patients are often relieved from their symptoms.

Monod, Saint-Herblain, Nantes Cedex 1. Valproate, levetiracetam, and benzodiazepines are most beneficial in the treatment of cortical tremors and myoclonus due to mhoclonique combined antiepileptic and antimyoclonic effects.

Epilepsia ; 40 suppl. The physical examination is usually normal.

KEPPRA – Lévétiracétam – Posologie, Effets secondaires, Grossesse – Doctissimo

Access to the full text of this article requires a subscription. Disease definition Benign adult familial myoclonic epilepsy BAFME is an inherited epileptic syndrome epilepsi by cortical hand tremors, myoclonic jerks and occasional generalized or focal seizures with a non-progressive or very slowly progressive disease course, and no signs of early dementia or cerebellar ataxia.

Wrightson Biomedical Publishing, Juvenile myoclonic epilepsy today. Cortical tremor unlike essential tremor usually has a poor response to beta blockers but improves with antiepileptic drugs.


The final known associated gene is EFHC1. Only comments written in English can be processed. However a number of quantitative MRI studies have reported focal or regional abnormalities of the subcortical and cortical grey matter, particularly the thalamus and frontal cortex, in JME patients.

Am J Hum Genet. Rogawsky, M, Noebels, JL, ed. Specialised Social Services Eurordis directory. Sleep deprivation is a major factor in triggering seizures in JME patients.

The jugenile diagnosis for JME is a good knowledge of patient history and the neurologist’s familiarity with the myoclonic jerks, which are the hallmark of the syndrome. JME and related syndromes: Association of HLA class II alleles in patients with juvenile myoclonic epilepsy compared with patients with other forms of adolescent-onset generalized epilepsy. Localization of idiopathic generalized epilepsy on chromosome 6p in families of juvenile myoclonic epilepsy patients.

Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted.